Preparation of difficol.

摘要

The subject disclosure discloses a chemical intermediate in antibiotic synthesis of the structure:
<Chemistry id="chema01" num="0001"><Image id="ia01" he="61" wi="167" file="IMGA0001.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry>wherein
<UnorderedLists id="ula01" listStyle="none"><ListItem>R, is H or OH and the asterisks indicate asymmetric carbon atoms. Compounds of this type may be obtained by fermentation with a strain of B. subtilis under aerobic conditions. Compounds of the above structure are biologically inactive but are converted by phosphorylation of the hydroxyl group to produce compounds of the structure: wherein</ListItem><ListItem>R<Sub>1</Sub> is H or OH, which are useful antibacterial substances having a broad spectrum of antibacterial activity.</ListItem></UnorderedLists>