| 摘要 |
NEW MATERIAL:A beta-(acetylamino)acrylic ester shown by the formula I (R is alkyl, or aryl). USE:A compound to be expected as a raw material for drugs, being converted to a beta-alanine derivative by reduction. PREPARATION:An alkali formylacetic ester shown by the formula II (M is Na, K, or Li) is reacted with a mineral acid salt of acetamide shown by the formula III (X is halogen, HSO4, or NO3) in the presence of a solvent, to give a compound shown by the formula I. The reaction is carried out at 50-150 deg.C preferably for about 1-20hr. A solvent (e.g., DMF, DMSO, THF, etc.) inert to the alkali formylacetic ester and the mineral acid salt of acetamide is prefer able as the solvent.
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