| 摘要 |
PURPOSE:To obtain an optically active isomer of the titled compound useful as an intermediate for pharmaceuticals, etc., from an inexpensive raw material, economically with simple chromatographic technique without using chemical conversion, by carrying out the optical resolution of the titled compound using a resolving agent containing a polysaccharide as an acitive component. CONSTITUTION:An optically active isomer of the compound of formula I or formula II (R is <=10C alkyl or substituted alkyl; Ar is aromatic group or heteroaromatic group; the group of formula III is a part of aromatic group or heteroaromatic group; n is 1-5), formula IV or formula V (R' and R'' are alkyl or substituted alkyl; one of them may be H) or formula VI, can be pro duced from an inexpensive racemic raw material economically on an industrial scale, by carrying out the optical resolution of the racemic compound with a resolving agent containing, as an active component, a polysaccharide, prefer ably a homoglycan having high regularity, especially cellulose, etc., giving a high-purity polysaccharide easily or its derivative wherein at least a part, prefer ably >=85% of the H of the OH is substituted with a 1-3C carboxylic acid, etc.
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