| 摘要 |
<p>Pharmaceutical compounds are described of the formula
<Chemistry id="chema01" num="0001"><Image id="ia01" he="16" wi="52" file="IMGA0001.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry>in which R' is (i) R<Sup>4</Sup>O(CH<Sub>2</Sub>CH<Sub>2</Sub>O)<Sub>n</Sub>(CH<Sub>2</Sub>)<Sub>m</Sub>- where R<Sup>4</Sup> is hydrogen or C, <Sub>5</Sub> alkyl, n is 0 or 1 to 5 and m is 1 to 7, or (ii) R<Sup>5-</Sup>X- where R<Sup>5</Sup> is a polar group and X is a C<Sub>6</Sub> 20 alkylene or a C<Sub>6 20</Sub> alkenylene radical containing from 1 to 3 double bonds, R<Sup>2</Sup> is a group of the formula A-B-where A is -COOH or
<Chemistry id="chema02" num="0002"><Image id="ia02" he="15" wi="21" file="IMGA0002.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry>where R<Sup>6 </Sup>is hydrogen or a protecting group, and B is C<Sub>1-6</Sub> alkylene, and R<Sup>3</Sup> is -COOH or
<Chemistry id="chema03" num="0003"><Image id="ia03" he="16" wi="21" file="IMGA0003.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry>where R<Sup>7</Sup> is hydrogen or a protecting group; or a salt or ester thereof.</p> |
