Method of sterilizing recombinant microorganism.

摘要

A method of sterilizing a recombinant microorganism by addition of a salt of chlorhexidine to a culture mixture of said recombinant microorganism before a physiologically active substance which is produced by cultivating said microorganism is extracted and purified from said culture is disclosed. According to this method, the complete sterilization of said recombinant microorganism can be performed, and the physiochemical or physiological properties of said substance are not essentially impaired by use of the salt of chlorhexdine.