发明名称 |
PREPARATION OF BIARYL COMPOUNDS |
摘要 |
<p>PREPARATION OF BIARYL COMPOUNDS Biaryl compounds are prepared by coupling an arylamine with an aromatic compound in the presence of an alkyl nitrite and 0.04-0.6 mol of an acid having a dissociation constant of at least 1.7 x 10-5 at 25.degree.C. and about 0.08-1.3 mols of a cuprous halide catalyst per mol of the arylamine. The invention has particular utility in the coupling with aromatic compounds of arylamines having acid-sensitive ar-substituents, e.g. flurbiprofen intermediates, such as 2-(4-amino-3-fluorobenzene)propionitrile and alkyl 2-(4-amino-3-fluorobenzene)propionates.</p> |
申请公布号 |
CA1209159(A) |
申请公布日期 |
1986.08.05 |
申请号 |
CA19840452610 |
申请日期 |
1984.04.24 |
申请人 |
ETHYL CORPORATION |
发明人 |
RAMACHANDRAN, VENKATARAMAN |
分类号 |
C07B37/04;B01J27/00;B01J27/122;B01J31/00;C07B31/00;C07B37/06;C07B61/00;C07C67/00;C07C69/616;C07C69/65;C07C253/00;C07C255/32;C07C255/33;C07C255/35;C07C255/58;(IPC1-7):C07C69/65;C07C121/66 |
主分类号 |
C07B37/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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