发明名称 Stable eburnamenine-14-one resinate prodn.
摘要 Prodn. of eburnamenine-14(15H)-one resinates of formula (I) comprises treating an acid addn. salt of (-) eburnamenine-14(15H)-one (II), e.g. the phosphate or hydrochloride, with a cation exchange resin contg. sulphonate gps. in alkali metal form. The reaction is carried out in polar solven, e.g. water or aq. EtOH at 50 deg. c for 10 hr. - The (II) salt is added at over 22 wt.% on the resin which pref. has particle size 50-100 microns and is a copolymer of styrene crosslinked with a small percentage of divinylbenzene.
申请公布号 ES8604955(A1) 申请公布日期 1986.08.01
申请号 ES19350005487 申请日期 1985.11.08
申请人 COVEX,S.A. 发明人
分类号 C07D461/00;A61K47/48;(IPC1-7):C07D461/00;A61K31/475 主分类号 C07D461/00
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