| 摘要 |
1-Ethyl 6-fluoro 7-(1-piperazinyl) 1,4-dihydro 4-oxo quinoline 3-carboxylic acid of formula (I) is made by (a) reacting diethanolamine with thionyl chloride in CHCl3 to give 2,2'-dichloro diethylamine; and (b) condensing this with 1-ethyl 6-fluoro 7-(1-piperazinyl) 1,4-dihydro 4-oxo quinoline 3- carboxylic acid (II) in ethanol or DMF in presence of triethanol-amine or pyridine at 80-200 deg.C, to obtain (I) and its acceptable salts.
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