摘要 |
5-Chloro 1-(1-(3-(2-oxo 1-benzimidazolinyl)propyl) 4-piperidinyl) 2-benzimidazolinone of formula (I) is made by phase transference reaction of 1-(3-chloro propyl) 2-benzimidazolinone with 5-chloro 1-(piperidin-4-yl) 2-benzimidazolinone under strong agitation, in presence of a catalyst, e.g. tetrabutyl ammonium hydrogen sulphate at below b.pt.. The aq. phase is aq. NaOH soln. and the organic phase is an immiscible solvent e.g. HC2Cl2.
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