| 摘要 |
1-(2-desoxy-D-erythropento or arabino-furanosyl and its 2-fluoro deriv.)-5-(R3-(CH2)n- CR1R2)-1H,3H-pyrimidin-2,4-dione and 2-one-4-imino derivs. of formula (I) and their acid addition salts are new (where R1, R2 independently are H or lower alkyl; R3 is halo, difluoro-methyl or trifluoro-methyl; R4 is H, hydroxy or fluoro; X is O or -NH- and n is O or 1. The glucidic gp. may have alpha or beta configuration). - Antivirals effect against Herpes viruses, such as Herpes simplex I. They may be administered in daily doses of 200-1200 mg, as 2-4 unit doses of 50-600 mg. - 1-(2-desoxy-beta-D -erythro-pentofuranosyl) -5-(2-chloroethyl)-(1H,3H) pyrimidine-2,4-dione and its acid addition salts. (0/0) GBAB- GB2125401 B Compounds of formula (I) wherein R1 and R2 represent independently hydrogen or lower alkyl, R3 represents halogen, CHF2 or CF3, R4 represents hydrogen, hydroxy or fluorine, X represents oxygen or imino, and n is 0 or 1, whereby the sugar radical is alpha or beta-glycosically bound to the pyrimidine ring; in free form or acid addition salt form.
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