| 摘要 |
<p>NEW MATERIAL:A compound expressed by formula I {R<1> represents (substituted) lower alkyl; R<2> represents hydroxy lower alkyl, cyano, lower alkylthio, 5-methyl-2-oxo-1,3-dioxolen-4-yl, carbonyl expressed by -CORA [RA represents (substituted) lower alkyl], etc.; R<3> represents H or lower alkyl; n is 1-3} or salt thereof. EXAMPLE:(Z)-7-[alpha-( 2-Amino-4-thiazolyl )-alpha-(methoxyimino)acetamide]-3-(1-cyano methyl-4-pyridinio)thiomethyl-DELTA<3>-cephem-4-carboxylate expressed by formula II. USE:An antibacterial agent against Gram-positive bacteria and Gram-negative bacteria. PREPARATION:A 3-pyridinylthiomethyl-DELTA<3>-cephem-4-carboxylic acid derivative expressed by formula III (R<4> represents H or amino-protecting group; R<5> represents H or COOH-protecting group) is reacted with a (substituted) lower alkyl halide or sulfonate expressed by formula IV (R<20> represents hydroxy lower alkyl, etc.; X represents halogen atom, etc.).</p> |
