| 摘要 |
NEW MATERIAL:A compound shown by formula I (R<1> is acyl; R<2> is alkyl; A is alkykl which may be replaced with OH; Y is O, S, CONH or NHCO; Het is 5-6-membered hetero ring which contains 1-3 hetero atoms consisting of O, S and N and may be condensed with benzene ring; R<3>-R<5> are H, alkyl, OH, SH, alkoxy, amino, carboxy, etc.,) or its salt. EXAMPLE:2-Hydroxy-4-[2-hydroxy-3-[(5-mercapto-1,3,4-thiadiazol-2-yl)thio] pro poxy]-3-propylacetophenone. USE:An SRS-A antagonist useful for preventing and remedying allergic diseases, ischemic cardiac diseases resulting from SRS-A, brain diseases, inflammations, etc. PREPARATION:For example, a halogen compound shown by formula II (X is halogen) is reacted with a compound shown by formula III (M is H or alkali metal; Y<2> is O or S) to give a compound shown by formula I when Y=Y<2>. |
