| 摘要 |
<p>Compounds acting as antagonists of the antidiuretic/and or vasopressor activity of arginine vasopressin have the formula <CHEM> wherein n is 4 or 5; X is (D- or L-)Tyr (R), (in which R is C1-C4 alkyl, D-Phe, D-Val, D-Leu, D-Ile, D-Nva, D-Nle, D-Cha, D-Abu, D-Thr, D-Asn, D-Gln, or D-Met; Y is Val, Ile, Thr, Ala, Lys, Cha, Nva, Met, Nle, Orn, Ser, Asn, Gln, Phe, Tyr, Gly, Abu or Leu; Z is (D-or L-)Arg, Orn or Lys; and Q is Orn(NH2), NHCH2CH2NH2, Val(NH2), Phe(NH2), Ile(NH2), Thr(NH2), Pro(NH2) or Tyr(NH2), provided that when Y is Val or Gln, R is also H.</p> |
