| 摘要 |
<p>NEW MATERIAL:A compound shown by the formula I (R<1> is H, 1-10C alkyl, or cation; R<2> is 3-8C alicyclic group; R<3> and R<4> are H, or protecting group). EXAMPLE:7alpha-Fluoro-16,17,18,19,20-pentanoyl-15-cyclopentyl-pGI2 methyl ester. USE:A remedy against diseases of circulatory organs. Having strong inhibitory action on blood platelet aggregation, useful against ischemic cardiac diseases, peripheral circulatory disorders, angina pectoris, myocardial infarction, etc. Also useful in dialysis of kidney and extracorporeal circulation. PREPARATION:A compound shown by the formula II (R<11> is 1-10C alkyl; R<9>, R<31>, and R<41> are protecting group) is fluorinated with a fluorinating agent of aminosulfate trifluoride type, deprotected, and subjected to ring formation by a well-known method, to give a compound shown by the formula I.</p> |
