| 摘要 |
PCT No. PCT/FR81/00134 Sec. 371 Date Jun. 23, 1982 Sec. 102(e) Date Jun. 23, 1982 PCT Filed Oct. 22, 1981 PCT Pub. No. WO82/01468 PCT Pub. Date May 13, 1982.A new galenic form with delayed release of METROCLOPRAMIDE, useful for gastric treatment, is formed by microgranules comprising a neutral core formed by a grain of an inert excipient comprising at least two components of the type belonging to the class formed by saccharose, starch, talc, desiccating silica, lactose and stearic acid, this neutral grain being provided with a first layer comprising METOCLOPRAMIDE, then a second outer layer formed by a microporous envelope comprising at least one natural and/or synthetic polymer belonging to the class formed by shellac, gum arabic, ethyl cellulose, cellulose acetophtalate, cellulose triacetate, polyoxyethyleneglycol, the methacrylates, styrene-acrylonitrile copolymer and polyvinylpyrrolidone in successive envelopes. |
