| 摘要 |
<p>The compounds have the general formula I <IMAGE> in which R<1> is hydrogen, an alkyl group with 1 to 6 carbon atoms, the phenyl group or a substituted phenyl group, a cycloalkyl group, a carboxyl group, alkoxycarbonyl group, carboxamide group or cyano group, R<2> is hydrogen or an alkyl group with 1 to 4 carbon atoms, R<3> is hydrogen, an alkyl group with 1 to 4 carbon atoms, a carboxyl group, alkoxycarbonyl group, carboxamide group or cyano group and R<4> is hydrogen, halogen, the cyano group, hydroxyl group, carboxamide group, an alkylthio group or alkoxy group with, in each case, 1 to 6 carbon atoms, each of which can optionally be substituted by substituted amino groups, an amino group or substituted amino group, a pyrrolidino, piperidino, hydrazino, morpholino, piperazino or substituted piperazino group, where, as indicated by broken bonds, ring C of the benzonaphthyridine framework can also be in partially hydrogenated form, and alkyls can be, in each case, straight-chain or branched, and they and their tautomeric forms and their salts and acid addition salts have positive inotropic and vasodilating properties and are suitable as pharmaceuticals for the treatment of heart failure, angina pectoris and/or hypertension.</p> |
