发明名称 |
Synthetic polymeric drugs. |
摘要 |
<p>A polymeric drug comprising an inert synthetic polymeric carrier combined through aminoacid or peptide spacers with a bioactive molecule, a targeting moiety, and an optional cross-linkage, comprises: (a) 5.0 to 99.7 mol % of units derived from N-(2-hydroxypropyl)methacrylamide, (b) 0.2 to 20.0 mol % of units derived from an N-methylacrylcylated peptide, the peptide groups being bound to a bioactive moiety, (c) 0.1 to 94.8 mol % of units derived from N-methacrylamide, N-methacrylic acid or an N-methacrylolated aminoacid or peptide, to which are bound a determinant capable of interacting with specific receptors on cell surfaces, (d) optionally, 0 to 5 mol % of units derived from an N-methacryloylated peptide, the peptide groups being bound to a linking group which is similarly to a similar peptide group attached to another polymer chain, and (e) optionally, as a bioassay label, 0 to 2 mol % units derived from N-methyacryloylated tyrosinamide.</p> |
申请公布号 |
EP0187547(A2) |
申请公布日期 |
1986.07.16 |
申请号 |
EP19850309560 |
申请日期 |
1985.12.31 |
申请人 |
CESKOSLOVENSKA AKADEMIE VED;CARLTON MEDICAL PRODUCTS LIMITED |
发明人 |
KOPECEK, JINDRICH THE INSTITUTE OF;REJMANOVA, PAVLA THE INSTITUTE OF;STROHALM, JIRI THE INSTITUTE OF;ULBRICH, KAREL THE INSTITUTE OF;RIHOVA, BLANKA THE INSTITUTE OF;CHYTRY, VLADIMIR THE INSTITUTE OF;LLOYD, JOHN B. DEPARTMENT OF BIOLOGICAL SCIENCES;DUNCAN, RUTH DEPARTMENT OF BIOLOGICAL SCIENCES |
分类号 |
A61K38/00;A61K;A61K31/00;A61K31/70;A61K45/00;A61K47/00;A61K47/48;A61P35/00 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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