| 摘要 |
PURPOSE:To produce the titled compound useful as an anti-allergic agent or its intermediate, in high yield, in short steps, by reacting a phthalide with a compound such as easily available sodium ethyl p-hydroxybenzoate, neutralizing the product with an acid, and reacting with a condensation agent. CONSTITUTION:The dibenzo[b,e]oxepine derivative of formula III [e.g. 11- oxodibenzo[b,e]oxepine-2-carboxylic acid ethyl ester] can be prepared by (1) reacting a phthalide with the compound of formula I (R<1> is lower alkyl; M is alkali metal or alkaline earth metal) (e.g. sodium salt of ethyl p- hydroxybenzoate), (2) neutralizing the reaction product with an acid such as acetic acid, and (3) reacting the resultant compound of formula II [e.g. 2-(4- ethoxycarbonylphenoxy)methylbenzoic acid] with a condensation agent such as trifluoroacetic anhydride. The starting compound of formula I is obtained easily by the reaction of the compound of formula IV with a metal alkoxide.
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