| 摘要 |
NEW MATERIAL:Dibenzo[b,e]oxepine derivative of formula I [R' is O-(CH2)m- NR<3>R<4> (m is 1-6; R<3> and R<4> are lower alkyl), NHR<5> (R<5> is lower alkyl, OCH2 CH(OR<6>)CH2OCH2CH3 (R<6> is H or acetyl) or OCH2CH2OCH2CH2OH; R<2> is S-NR<7>R<8> (R<7> and R<8> are lower alkyl) or 4-(lower alkyl)piperazino] or its salt. EXAMPLE:N-Hexyl-11-(2-dimethylaminoethyl)thio-6, 11- dihydrodibenzo[b, e]oxepi ne-2-carboxamide. USE:It has anti-allergic activity and is useful as a medicinal drug such as antiasthmatic, etc. Administered preferably by oral administration or by injection. PREPARATION:The compound of formula I can be prepared according to the reaction formula, by reacting the compound of formula II with thionyl chloride, and reacting the reaction product with the compound of formula III.
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