| 摘要 |
PURPOSE:To enable the concentration and/or purification of a solution of the titled compound in high efficiency, by the reverse osmosis using a loose reverse osmosis membrane and/or by the desorption method comprising the adsorption of the titled compound to an adsorbent in the form of free carboxylic acid, the conversion of the acid to a salt, and the elution with an aqueous solution. CONSTITUTION:The compounds having low molecular weight are removed from a beta-lactam compound (e.g. antibiotic substance such as oxacephalosporin) without using heat, by the reverse osmosis utilizing a loose osmotic membrane to effect the concentration of the solution in high efficiency. As an alternative method, the above antibiotic substance adsorbed to an adsorbent in the sate of free carboxylic acid is eluted with a basic aqueous solution containing an alkali metal hydroxide, or neutralized with said basic solution and eluted with water or an aqueous solvent to effect the purification of the solution in high efficiency while suppressing the side reactions. The concentration and purification of the solution can be carried out further efficiently and economically, by combining the above steps, and using the purified liquid obtained by the latter process as the feed solution of the former process. |
