VERFAHREN ZUR HERSTELLUNG VON 9-(2-HYDROXYAETHOXYMETHYL)-GUANIN, NEUE, IN DIESEM VERFAHREN VERWENDBARE ZWISCHENPRODUKTE UND VERFAHREN ZUR HERSTELLUNG DIESER NEUEN ZWISCHENPRODUKTE

摘要

There is disclosed a process for preparing 9-(2-hydroxyethoxymethyl)-guanine (acyclovir) of the formula IV IV wherein a novel compound of the formula I I wherein R and R' may be the same or different and represent hydrogen, (C1-C8)acyl or benzyl and R1 represents (C1-C8)acyl, is hydrolyzed under mild basic conditions. Also disclosed is the novel compound of the formula I, a process for the preparation thereof by condensing a novel compound of the formula II II with a compound A-CH2-O-CH2CH2-OR' (A is a leaving group, Q is hydrogen or a leaving group), the novel compound of the formula II and a process for the preparation thereof by means of condensing glyoxal hydrate and a compound of the formula V V