6-Purinyl N-(2-chloroethyl) carbamate and thiocarbamate, a process for their preparation and use thereof.

摘要

The invention relates to 6-purinyl N-(2-chloroethyl) carbamate and thiocarbamate of the general formula I
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in which X stands for an oxygen or sulphur atom, and to a process for their preparation by reacting a purine derivative of the general formula II
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(hypoxanthine or 6-mercaptopurine, respectively) with 2-chloroethylisocyanate. The compounds of formula I show a remarkable antineoplastic effect in vitro and in vivo, and consequently provide a potential treatment for malignant neoplastic diseases in mammals.