发明名称 |
FREMGANGSMAATE TIL FREMSTILLING AV BASISK SUBSTITUERTE ALKYLTEOFYLLINDERIVATER. |
摘要 |
<p>There is described a process for the production of theophylline derivatives of the formula <IMAGE> I where T is the theophyllinyl-(7)-residue, Alk is a straight or branched alkylene chain having 2 to 4 carbon atoms, R is hydrogen or a methyl group, n is 1 or 2 with the proviso that two hydroxy groups of the phenyl ring cannot be in the 3,4-positions by reacting an aminoalkyltheophylline of the formula <IMAGE> II with a bromoketone of the formula <IMAGE> III where R' is a lower alkyl group and the two -OCOR' groups of the phenyl ring cannot be in the 3,4 positions to an intermediate compound of the formula <IMAGE> IV and subsequently hydrolytically splitting off the R'CO protective group wherein the bromoketone of formula III is produced free of dibromide by bromination of a ketone of the formula <IMAGE> V followed by treatment with a lower trialkyl phosphite.</p> |
申请公布号 |
NO154014(C) |
申请公布日期 |
1986.07.02 |
申请号 |
NO19790002110 |
申请日期 |
1979.06.22 |
申请人 |
DEUTSCHE GOLD- UND SILBER-SCHEIDENANSTALT VORM ROESSLER |
发明人 |
KLINGLER, KARL HEINZ;HITZEL, FRANZ;BICKEL, ERICH |
分类号 |
C07D473/08;(IPC1-7):C07D473/08 |
主分类号 |
C07D473/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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