| 摘要 |
<p>NEW MATERIAL:2',3'-dideoxy-2'-fluorokanamycin A shown by the formula I and its acid addition salt. USE:An antibacterial agent. showing high antibacterial activity also against bacteria resistant to kanamycin. PREPARATION:For example, a compound [e.g., 6-0-(2-0-acetl-4,6-0-cyclohwxyli dene-3-deoxy-3-tosylamino-alpha-D-glucopyranosyl)-1,3-bis-N-tosyl-2-de -oxystreptamine, etc.] shown by the formula II (Y is NH2-protecting group; B and D are OH- protecting group) is reacted with a compound(e.g., 6-azido-4-0-benzoyl-2,3- dideoxy-2-fluoro-ribo-hexopyranosyl bromide, etc.) shown by the formula III (A is OH-protecting group) in an anhydrous organic solvent (preferably dichromomethane) at 80-100 deg.C, the azido group is reduced, and deprotected.</p> |
