TETRALINER, FREMGANGSMAADER TIL DERES FREMSTILLING, DERES ANVENDELSE TIL FREMSTILLING AF ANTHRACYCLINONER OG GLYCOSIDER (ANTHRACYCLINER) FREMSTILLET UD FRA DISSE ANTHRACYCLINONER

摘要

The present invention relates to new tetralins and their use for the preparation of anthracyclinones and anthracyclins. These tetralins contain at least one chiral carbon atom and correspond to the formula (V) below: (V) in which: R1 and R2 denote a hydrogen atom, or a halogen atom or the group OCH3, provided that one of the two substituents (R1 or R2) must denote OCH3, and R3 denotes a hydrogen atom or the OR' group, R' being hydrogen or a hydroxyl-protecting group. Application: synthesis of glycosides of great therapeutic value.