TETRA-SUBSTITUTED BENZENE DERIVATIVES

摘要

Novel compounds of the general formula < IMG > I wherein X represents an oxygen or sulphur atom or hydroxyimino; Y represents methylene or imino; R1 represents a hydroxy, phosphonooxy, glycosyloxy, acylated glycosyloxy, acyloxy or lower alkoxycarbonyloxy; R2 represents lower alkoxy, lower alkenyloxy or lower alkylthio; R3 represents lower alkoxy; R4 represents lower alkyl, p-lower-alkoxy-benzoyl or a substituted or unsubstituted phenyl, benzyl, pyridylmethyl, furfuryl, tetrahydrofurfuryl, thenyl tetrahydrothenyl, pyrrolylmethyl, pyrrolinylmethyl or pyrrolidinylmethyl group, with the proviso that when R4 represents alkyl, a phenyl including lower alkyloxy phenyl, benzyl or p-hydroxybenzyl, Y does not represent a methylene radical; and with the further proviso that when R4 represents p-methoxybenzyl and Y represents methylene, R2 and R3 are different, and pharmaceutically acceptable salts thereof, possess antiviral activity. The compounds of formula I can be prepared by various methods.