| 摘要 |
NEW MATERIAL:A salt compound composed of acetylsalicylic acid of formula I (n is 0 or 1; R is quinolyl, naphthyl, cyclohexyl, etc.). EXAMPLE:beta-Naphthylguanidine acetylsalicylate. USE:An improver for microcirculatory system having remarkable peripheral vessel dilating activity. It has higher water-solubility than acetylsalicylic acid, and can be administered by intravenous or intramuscular infection. It exhibits little side effects such as gastric disorder by oral administration. PREPARATION:The compound of formula I can be prepared by reacting the guanidine of formula II (HX is hydrogen halide or sulfuric acid) or its salt with acetylsalicylic acid at room temperature. The molar ratio of guanidine to acetylsalicylic acid in the reaction is preferably 1.1-1.2:1. |
