| 摘要 |
Compounds of Formula: <CHEM> in which: A is -NR-(CH2)n-NR2 or -NR-(CH2)n <CHEM> P is Phe, Ile, Phe(4'-Alk), Tyr or Tyr(Alk); X is a D or L isomer of Val, Nva, Leu, Ile, Pba, Phe, Phe(4'-Alk), Trp, Nle, Cha, Abu, Met, Chg, Tyr or Tyr(Alk); Y is Val, Ile, Abu, Ala, Chg, Gln, Lys, Cha, Thr, Nle, Phe, Leu or Gly; Z is Gly, Sar, a single bond or a D or L isomer of Pro, INCREMENT <3>-Pro, Ala or N-Me-Ala; R<1> is, each, hydrogen or methyl; n is an integer from 2-8; and R is, each, hydrogen or methyl; or a pharmaceutically acceptable salt thereof. The compounds are V1-vasopressin antagonists and are useful in the treatment of hypertension and cardiac ischaemic diseases. |
