| 摘要 |
Cis-4-(4-(4-((2-(2,4-dichloro phenyl)2-bromomethyl 1,3-dioxolan-4-yl) methoxyphenyl)2,4-dihydro 2-(1-methyl propyl) 3H-1,2,4-triazol-3-one is made by reaction of 4-(4-(4-(4-hydroxy phenyl) 1-piperazinyl) phenyl)2,4-dihydro 2-(1-methyl propyl)3H-1,2,4-triazol-3-one in 5-10% molar excess with a cpd. of formula (I), in which Z is a reactive gp., e.g. halogen, methylphenoxy or 4-methyl phenylsulphonyloxy. Reaction is carried out in an inert organic solvent at 60-90 deg.C.
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