| 摘要 |
NEW MATERIAL:A compound shown by the formula I (R<1> is H, OH, acetoxy, etc.: R'1 is H, OH, halogen, etc.; R2 is H, OH, methoxycarbonyloxy, etc.; R'2 is H, or halogen; with the ptoviso that R1 and R2 are bonded to show single bond, group shown by the formula II, etc.; R3 is H, OH, or methoxy; R4 is aldehyde which may be protected; R5 is H, lower alkanoyl, or phenylcarbonyl). EXAMPLE:3-0-Acetyl 4''-0-isovaleryl-4''-0-methylosin. USE:An antibacterial agent. Showing higher antibacterial activity against bacteria resistant to tylosin. PREPARATION:For example, a tylosin analog substance such as 3-0-acetyl-4''-0- isovaleryltylosin, etc. as a starting raw material is subjected to conversion of saccharide residue by well-known method such as reaction with acetic anhydride.
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