| 摘要 |
PURPOSE:The titled vaccin for oral administration that contains, as an antigen, cell bodies of periodontosis-causative bacterium or their cillia or extract. CONSTITUTION:The objective vaccin for preventing periodontosis is obtained by using, as an antigen, the whole cell bodies of periodontosis causative bacteria, preferably bacteriodes gingivalis and Actimonyces viscosus or their cillia or their extract. When it is given orally, the fixation of the bacteria causing periodontosis is prevented to inhibit their proliferation. This prevention is higher in safety than parenteral administration. The dose of the somatic antigen is 0.1-10ml of the vaccin containing 10<4>-10<10>/ml of the whole cell bodies and is given continuously for 3-15 days. Fimbrila antigen and extract antigen are given, respectively, 0.1-10ml of 0.01-10mg/ml concentratin for 3-15 days.
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