| 摘要 |
NEW MATERIAL:The compound of formula I (R<1> is H, halogen, alkyl or alkoxy; R<2> is H or CH3; R<3> is H, CH3 or propoxy; R<4> is H or CH3; R<2>, R<3> and R<4> are not H at the same time). EXAMPLE:2-[2-(3,5-Dimethyl)pyridylmethylsulfinyl]-5-fluorobenzoxazole. USE:Potassium ion dependent adenosintriphosphatase activity inhibitor, and gastric acid secresion suppressing agent. PREPARATION:The compound of formula I can be prepared by reacting the compound of formula II with the compound of formula III (X is Cl or Br) in a solvent in the presence of a small amount of a crown ether, and oxidizing the resultant compound of formula IV with an oxidizing agent (preferably m- chlorobenzoic acid) in a solvent such as chloroform at -10-+30 deg.C. |
