发明名称 PYRROLIDINONE DERIVATIVES
摘要 Compounds of the formula <IMAGE> wherein R1 is hydrogen or alkyl of 1 to 4 carbon atoms; R2 is 2-, 3- or 4-pyridyl, phenyl or mono- or disubstituted phenyl, where the substituents are each individually alkoxy of 1 to 2 carbon atoms, fluorine, chlorine, bromine, trifluoromethyl, alkyl or 1 to 4 carbon atoms, hydroxyl or nitro; and R3 and R4 are each independently hydrogen or alkyl of 1 to 4 carbon atoms; or R3 and R4, together with each other and the nitrogen atom to which they are attached, form an unsubstituted or methyl-substituted, saturated 5- or 6-membered heterocycle which may contain an additional oxygen or nitrogen heteroatom, or form an imidazole ring; where the aminomethyl substituent is attached to the 4- or 5-position or the pyrrolidine ring, and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as the salts are useful as nootropics and antihypoxics.
申请公布号 ZA8407755(B) 申请公布日期 1986.06.25
申请号 ZA19840007755 申请日期 1984.10.03
申请人 BOEHRINGER INGELHEIM INTERNATIONAL G.M.B.H. 发明人 KARL HEINZ WEBER;GERHARD WALTHER;CLAUS SCHNEIDER;DIETER HINZEN;FRANZ JOSEF KUHN;ERICH LEHR
分类号 A61K31/40;A61K31/4015;A61K31/415;A61K31/44;A61K31/4427;A61K31/445;A61K31/495;A61K31/535;A61P25/02;A61P25/04;A61P25/28;C07D207/12;C07D207/26;C07D207/27;C07D401/06;C07D403/06;C07D521/00 主分类号 A61K31/40
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