Proline derivatives

摘要

Proline derivatives of the formulae: <IMAGE> (I) <IMAGE> <IMAGE> (II) <IMAGE> <IMAGE> (III) wherein R1 through R11 have defined values, and acid- and base-addition salts thereof, and equilibrium addition compounds of the aldehyde group thereof; processes for their preparation; pharmaceutical compositions; and intermediates for preparing said proline derivatives. The proline derivatives are human leukocyte elastase inhibitors which are useful, for example, in treating pulmonary emphysema.