| 摘要 |
A compound of formula (I) <IMAGE> (I) or a pharmaceutically acceptable salt thereof, in which R1 is hydrogen, halogen, or trifluoromethyl; R2 is hydrogen or halogen; R3 is hydrogen or methyl; R4 is -O(CH2)a CO2H or an ester or amide derivative thereof, O(CH2)bM or -CO2H or an ester or amide derivative thereof wherein a is an integer from 1 to 6, b is an integer from 2 to 7, and M is hydroxy, C1-6 alkoxy or <IMAGE> wherein R6 and R7 are each hydrogen or C1-6 alkyl or <IMAGE> together form a five or six membered ring; R5 is C1-6 alkyl; C1-6 alkyl substituted by carboxy or esters and amides thereof; or phenyl optionally substituted by C1-6 alkyl, halogen, alkoxy or trifluoromethyl; R8 is hydrogen or C1-6 alkyl or R8 together with R5 form a carbocyclic ring; and n is 1 or 2. Processes for preparing these compounds and their use in therapy is also described.
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