| 摘要 |
<p>PURPOSE:To obtain a polypeptide usable for medicines having a morphineagonistic activity and analgesic action at a low cost in large quantities, by condensing a tetradecapeptide having improved solubility in solvents and most suitable for liquid- phase method, with a penta peptide. CONSTITUTION:A pentapeptide of formula I: (the amino acid configuration 1-5 has a pharmacological action per se) having a protecting group is reacted with a decapeptide of formula II having a protecting group by fragment condensation, and the protecting group of the nonadecapeptide thus obtained is eliminated to form the desired peptide of formulaIII. Preferably, the raw material is dissolved in a solvent, e.g. dimethyl formamide, and reacted with nitrous acid to give an azide. EFFECT:High purity and yield with completely suppressed racemization.</p> |
