| 摘要 |
PCT No. PCT/JP81/00374 Sec. 371 Date Jul. 28, 1982 Sec. 102(e) Date Jul. 28, 1982 PCT Filed Dec. 9, 1981 PCT Pub. No. WO82/02045 PCT Pub. Date Jun. 24, 1982.Pyridine derivatives of the formula: <IMAGE> or pharmaceutically acceptable acid addition salts thereof, wherein R1, R2, R3 and R4 are the same or different and each represents hydrogen atom or lower alkyl group, or R1 and R2, or R3 and R4 together with the adjacent nitrogen atom form a heterocycle, A1 and A2 are the same or different and each represents alkylene or hydroxy-substituted alkylene group, Y1 and Y2 are the same or different and each represents oxygen or sulfur atom, and Z represents <IMAGE> These compounds show pharmacological activities such as potentiating activity for leukocyte phagocytosis, potentiating activity for macrophage phagocytosis, potentiating activity for the production of rosette forming cells in the spleen and anti-adjuvant arthritis activity, and are useful as medicines. |
