发明名称 |
PROCESS FOR THE PREPARATION OF CHIRAL HYDANTOINS, AND A NOVEL HYDANTOIN PRODUCED BY SAID PROCESS AND A PHARMACEUTICAL COMPOSITION CONTAINING IT |
摘要 |
A process for preparing a chiral hydantoin aldose reductase inhibitor of the formula:
<CHEM>
wherein X is chloro or fluoro, by the strong acid solvolysis of an alpha-methylbenzylhydantoin of the formula:-
<CHEM>
<??>Also disclosed is a process for preparing compound (I) from a halochromanenene of the formula:
<CHEM>
which processes proceeds through intermediate (V). Also covered are novel intermediates prepared in the above process, and the novel chiral hydantoin of the formula (I) in which X is chloro and a pharmaceutical composition containing it. |
申请公布号 |
DE3174610(D1) |
申请公布日期 |
1986.06.19 |
申请号 |
DE19813174610 |
申请日期 |
1981.03.24 |
申请人 |
PFIZER INC. |
发明人 |
SARGES, REINHARD |
分类号 |
A61K31/415;A61P3/08;A61P3/10;A61P25/02;A61P25/18;A61P27/02;A61P27/12;C07D311/68;C07D491/04;C07D491/10;C07D491/107;(IPC1-7):C07D491/107 |
主分类号 |
A61K31/415 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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