| 摘要 |
Pteridines of the formula <IMAGE> in which R2 denotes the piperazino or N-formylpiperazino group, R4 denotes a dialkylamino, phenylalkylamino, N-alkylphenylalkylamino, pyrrolidino, piperidino, morpholino, thiomorpholino, 1-oxidothiomorpholino, thiazolidino or 1-oxidothiazolidino group, R6 denotes a hydrogen atom or an alkyl or phenyl group and R7 denotes an alkylamino group, dialkylamino, phenylalkylamino, N-alkylphenylalkylamino, piperidino, morpholino, thiomorpholino, 1-oxidothiomorpholino or piperazino group, where in the radicals R4, R6 and R7 each alkyl moiety can in each case contain 1 to 3 carbon atoms and at the same time one or both alkyl groups having 2 or 3 carbon atoms of the radicals R4 and R7 can be substituted in the 2- or 3- position in each case by a hydroxyl group, and their acid addition salts. These, if R2 represents the N-formylpiperazino group, are useful intermediates for the preparation of the pteridines of the formula I in which R2 represents the piperazino group, which have useful pharmacological properties, in particular antithrombotic action, metastases-inhibiting action and an inhibitory action on tumour growth. The novel compounds can be prepared by processes known per se. |
