| 摘要 |
PURPOSE:To provide the titled composition having remarkably mitigated bitter taste, resistant to moisture-absorption, agglomeration, deliquescence, and hydrolysis, administrable in the form of powder, etc., and applicable at continuously adjustable dose, by compounding meclofenoxate hydrochloride with a cyclodextrin. CONSTITUTION:The objective composition contains meclofenoxate hydrochloride, a cyclodextrin and if necessary other additives. The cyclodextrin is especially preferably beta-cyclodextrin, and the amount is more than equimolar, preferably large excess to the meclofenoxate hydrochloride used as a main drug component. The inclusion is preferably carried out by the fluidized layer granulation method, by blowing dry air to as mixture of meclofenoxate hydrochloride and cyclodextrin from the bottom to effect the floatation of the mixture, and spraying water to the floating mixture from the top. The titled composition is used preferably in the form of powder, granule, or dry syrup. |
