| 摘要 |
NEW MATERIAL:1-Benzoxepin-5-one derivative of formula I (A is lower alkoxy, halogen; Y is piperizino morpholino, formula II (R<1> is 1-3C alkyl), formula III (R<2>, R<3> are H, 1-5C alkyl, aralkyl) where, when A is halogen, Y is a group other than piperizino]. EXAMPLE:4-(N-Methylpiprazinyl) methyl-8-chloro-2, 3, 4, 5-tetrahydro-1-benzoxe pine-5-one hydrochloride. USE:A drug for improving and treating the symptoms based on organic disorders in brain and pathergasia. For example, it is used for brain infarction sequela, cerebroarteriosclerotic sequela, senile dementia, amnesia, depression, or neuropathy. PREPARATION:A compound of formula IV is allowed to react with a gamma- lactone in the presence of a base and the product is treated with an acid, then heated together with a compound of formula IV to give the compound of formula I.
|
