摘要 |
NEW MATERIAL:A compound of formula I (R<1>CO, R<2>CO are residues of natu rally occurring fatty acids where at least one is residue of docosahexaenoic acid; R<3> is H, CH2CH2N<+>(CH3)3, CH2CH2N<+>H3, formulas II-V). EXAMPLE:1,2-Didocosahexaenyl-Sn-3-glycerophosphorylcholine. USE:Liposome, cholesterol-lowering agent, preventive for thrombosis: is shows high stability to oxidation. PREPARATION:For example, a deacylated phospholipid such as glycerylphosphorylcholine or glycerylphosphorylethanolamine or its cadmium salt is allowed to react with an anhydride, chloride or imidazole salt of docosahenxaenoic acid in the presence of a catalyst such as 4- dimethylaminopyridine in a solvent such as dichloromethane at room temperature under stirring.
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