发明名称 |
PROCESS FOR ISOLATING TETRACYCLINES |
摘要 |
<p>The subject of this invention is a method for isolating tetracyclines from the broth after the biosynthesis or from the mother liquor after isolating crude bases by means of ion-exchange and sorption resins. The broth or the acid mother liquor are passed through a bed of slightly alkaline anion-exchange resin with the functional groups blocked by a mineral acid anion. The antibiotic containing eluate is adsorbed on the bed of macroporous resin and then desorbed by washing with a 15-60% aqueous acidified solution af acetone or of methanol. The pure compound is isolated from the eluate by a well-known method. The beds of anion-exchange and sorption resins are regenerated with an aqueous solution of acetone or of methanol containing to 80% by volume of the organic solvent with addition of 0,4-6% by weight of sodium or potassium hydroxide or of ammonia.</p> |
申请公布号 |
IN157029(B) |
申请公布日期 |
1986.01.04 |
申请号 |
IN1983CA44019 |
申请日期 |
1983.04.15 |
申请人 |
INSTYTUT CHEMII PRZEMYSLOWEJ |
发明人 |
HEROPOLITANSKI RYSZARD;MUCHA BARBARA;SOCHACKA JOLANTA;MICHAISKA LUCYNA;CZARNY KAZIMIERZ;STASIAK MARIA |
分类号 |
C07C231/24;C07C67/00;C07C231/00;C07C237/26;C12P29/00;(IPC1-7):C07C103/19 |
主分类号 |
C07C231/24 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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