发明名称 |
INNESLUTNINGSKOMPLEX BASERAT PA CYKLODEXTRIN OCH INDOMETACIN, SETT ATT FRAMSTELLA KOMPLEXET SAMT FARMACEUTISK BEREDNING DERAV |
摘要 |
The invention relates to an inclusion complex of 1-(p-chloro-benzoyl)-5-methoxy-2-methyl-indol-3-yl-acetic acid (indomethacin) and cyclodextrin of a molar ratio of about 2:1. The inclusion complex can be prepared by reacting about 2 moles of alpha or beta cyclodextrin with about 1 mole of 1-(p-chloro-benzoyl)-5-methoxy-2-methyl-indol-3-yl-acetic acid under heating in the presence of an organic solvent which dissolves indomethacin and does not form a stable complex with cyclodextrin. The new complex is at least as active antiinflammatory agent as indomethacin and at the same time shows substantially less ulcerative side-effect. |
申请公布号 |
SE445353(B) |
申请公布日期 |
1986.06.16 |
申请号 |
SE19790000479 |
申请日期 |
1979.01.18 |
申请人 |
CHINOIN GYOGYSZER ES VEGYESZETI TERMEKEK GYARA RT |
发明人 |
J * SZEJTLI;L * SZENTE;A * DAVID;S * VIRAG;G * SEBESTYEN;A * MANDI |
分类号 |
A61K31/405;A61K47/40;A61K47/48;C07D209/28;C08B37/00;(IPC1-7):C08B37/16;A61K31/715 |
主分类号 |
A61K31/405 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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