| 摘要 |
NEW MATERIAL:A compound of formula I [A is single bond, methylene, ethyl ene, vinylene; B is 4-8-membered hydrocarbon ring which may be substituted with O, N, S; T is O, S; R<1> is formula II (R<5>, R<6> are H, halogen), alkyl; R<2> is H, 1-6C alkyl; R<3> is H, halogen, hydroxyl; when B forms a ring, R<4> is the formula: -U-(CH2)n-COOR<8> (U is O, S; R<8> is H, 1-6C alkyl; n is 0, 1-10)], and its non-toxic salts. EXAMPLE:7-(p-Hexyloxybenzoyl)amino-2-(r-tetrazolyl)benzofuran. USE:Leucotriene antagonist, phospholipase inhibitor. PREPARATION:A carboxylic acid of formula III or its corresponding dithionic acid is allowed to react with an amine of formula IV to form an amide bond, when needed, saponified to give a compound of formula I.
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