| 摘要 |
Compounds of the formula: <IMAGE> wherein R1 stands for hydrogen or a defined hydrocarbyl or halogenoalkenyl radical, R2 stands for a defined hydrocarbyl, halogenoalkenyl or furylmethyl radical, R3 is a substituent at position (a) or (b) and stands for a hydroxy or defined alkoxy or alkanoyloxy radical, R4 stands for a defined alkoxy, cyanoalkoxy or alkenyloxy radical or a defined amino acid residue or peptide residue, and n stands for 1, 2 or 3, and pharmaceutically-acceptable salts thereof. Processes for the manufacture of the compounds. Pharmaceutical compositions comprising one of the compounds and a pharmaceutical diluent or carrier. The compounds are antagonists at the opiate receptors, and most of them are selective delta -receptor antagonists. |
