| 摘要 |
1,151,971. Piperonyl-piperazines. SCIENCE UNION ET CIE, SOC. FRANCAISE DE RECHERCHE MEDICALE. 29 June, 1967 [30 June, 1966], No. 30012/67. Heading C2C. Piperonyl-piperazines of general Formula I and their physiologically acceptable salts in which Ar is a phenyl, tolyl, xylyl or fluorophenyl radical and A is -CH 2 CH 2 CH 2 CO-, -CH 2 - CH(CH 3 )-CO- or -CH 2 CH 2 CH 2 CHOH-, the -CO- or -CHOH- group being joined directly to Ar, are prepared by reacting 1- piperonyl-piperazine with a propiophenone of the general formula Ar.CO.CH(CH 3 ).CH 3 in the presence of paraformaldehyde and hydrochloric acid, or with an aroylalkyl chloride of formula Ar.CO.(CH 2 ) 3 .Cl, and the carbonyl derivative so obtained may be reduced by lithium aluminium hydride. Pharmaceutical compositions comprise a compound I together with a suitable excipient, are administered orally, rectally or parenterally and possess neuroleptic, vasodilatory, adrenolytic and anti-emitic activity.
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