发明名称 1-aryloxypropanolamines
摘要 Disclosed are novel compounds having the formula <IMAGE> wherein R1 is a hydrogen or halogen atom, a lower alkyl, lower alkoxy, lower alkoxy lower alkyl, lower alkenyl, lower alkenyl oxy, cyano, hydroxy, trifluoromethyl, nitro, amino, aminocarbonylmethyl, lower monoalkylamino, lower dialkylamino group; R2 is a hydrogen or halogen atom, cyano, lower alkyl or lower alkoxy or acylamino group; R3 is a hydrogen or halogen atom, a lower alkyl or lower alkoxy group, while R2 and R3 together can also be a butadienyl or methylene dioxy group; R4 is a hydrogen atom or a lower alkyl group; R5 is a chlorine atom or a trifluoromethyl group; X is an alkylene group; and the non-toxic, pharmaceutically acceptable acid addition salts thereof. The compounds are suitable for treatment and prophylaxis of hypertension.
申请公布号 US4594344(A) 申请公布日期 1986.06.10
申请号 US19850755044 申请日期 1985.07.15
申请人 BOEHRINGER INGELHEIM KG 发明人 KOEPPE, HERBERT;ABELE, DECEASED, WOLFGANG;ESSER, FRANZ;GAIDA, WOLFRAM;HOEFKE, WOLFGANG
分类号 A61K31/54;A61P9/12;C07D285/30;(IPC1-7):C07D285/30;C07D417/12 主分类号 A61K31/54
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