发明名称 |
Pharmaceutically active salt derivative of 3-hydroxy -5-(hydroxymethyl)-2-methylisonicotinaldehyde phosphate. |
摘要 |
<p>The present invention relates to a novel pharmacologically active salt derivative, constituted by 4-(1-pyrrolidinyl)-1-(2,4,6-trimethoxy-phenyl)-1-butanone 3-hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde-5-phosphate, to the process for the production thereof, and to the related pharmaceutical compositions. Said salt derivative is produced by reacting 3-hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde-5-phosphoric acid with 4-(1-pyrrolidinyl)-1-(2,4,6-trimethoxyphenyl)-3-butanone in an organic solvent and subsequently crystallizing the reaction product. Said salt derivative carries out an important pharmacological activity as inhibitor of platelet aggregation with vasodilative action.</p> |
申请公布号 |
EP0183002(A1) |
申请公布日期 |
1986.06.04 |
申请号 |
EP19850112179 |
申请日期 |
1985.09.25 |
申请人 |
LABORATORIO ITALIANO BIOCHIMICO FARMACEUTICO LISAPHARMA S.P.A. |
发明人 |
ZAGNOLI, GIORGIO;CONTE, UBALDO;COLOMBO, PAOLO |
分类号 |
C07D295/108;C07F9/58;(IPC1-7):C07F9/58;A61K31/675;C07D295/10 |
主分类号 |
C07D295/108 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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