| 发明名称 |
NOVEL PEPTIDASE INHIBITORS |
| 摘要 |
<p>This invention relates to analogs of peptidase substrates in which the amide group containing the scissile amide bond of the substrate peptide has been replaced by an activated electrophilic ketone moiety. These analogs of the peptidase substrates provide specific enzyme inhibitors for a variety of proteases, the inhibition of which will have useful physiological consequences in a variety of disease states.</p> |
| 申请公布号 |
GR860321(B) |
申请公布日期 |
1986.06.04 |
| 申请号 |
GR19860100321 |
申请日期 |
1986.02.03 |
| 申请人 |
MERRELL DOW PHARMACEUTICALS INC. |
发明人 |
KOLB MICHAEL;JUNG MICHEL;BURKHART JOSEPH;GERHART FRITZ;GIROUX EUGENE;SCHIRLIN DANIEL;NEISES BERNHARD |
| 分类号 |
C07K5/00;A61K31/13;A61K31/16;A61K31/165;A61K31/195;A61K31/215;A61K31/22;A61K38/00;A61K38/55;A61P7/02;A61P7/06;A61P9/12;A61P13/02;A61P15/00;A61P17/00;A61P29/00;A61P31/04;A61P35/00;A61P43/00;C07C67/00;C07C213/00;C07C225/02;C07C225/16;C07C227/00;C07C227/16;C07C227/18;C07C229/02;C07C229/22;C07C229/24;C07C229/26;C07C233/31;C07C237/02;C07C237/06;C07C237/12;C07C237/20;C07C237/22;C07C239/00;C07C271/22;C07C279/18;C07D207/16;C07D209/42;C07D498/10;C07K1/113;C07K5/02;C07K5/04;C07K5/06;C07K5/062;C07K5/08;C07K5/083;C07K5/097;C07K7/06;C07K14/81;C12N9/99 |
主分类号 |
C07K5/00 |
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